A fault on a train at Urmston means some lines are blocked.
Trains running between Manchester Oxford Road and Warrington Central may be cancelled, revised or delayed by up to 45 minutes.
Disruption is expected until 19:30.
Trains are no longer affected by the earlier broken down train at Deansgate.
Northern customer advice:
You can use your ticket at no extra cost on alternative Northern or TransPennine Express services via any reasonable route.
Services between Manchester stations and Liverpool Lime Street via Newton-le-Willows are not affected.
Check before you travel:
You can check your journey using the National Rail Enquiries real-time Journey Planner.
Compensation:
You may be entitled to compensation if you experience a delay in completing your journey today. Please keep your train ticket and make a note of your journey, as both will be required to support any claim.